abstract：:Progression of follicular lymphoma (FL) to a higher-grade lymphoma occurs in 25% to 60% of cases and frequently indicates a poor prognosis. The transformation is accompanied by alteration in morphologic features and clinical behaviors. Herein, we report a case of FL occurring in a 59-year-old woman with the developmen...

journal_title：American journal of clinical pathology

authors： Young KH,Xie Q,Zhou G,Eickhoff JC,Sanger WG,Aoun P,Chan WC

更新日期：2008-01-01 00:00:00

abstract：:Remarkable improvements have been made in blood safety since the onset of the HIV epidemic. However, the current paradigm does not prevent all transfusion-transmitted infections and is reactive to new agents, thus accepting that some patients may be harmed before preventive measures are introduced. Several methods are...

journal_title：American journal of clinical pathology

authors： McCullough J

更新日期：2007-12-01 00:00:00

abstract：:Timely communication of significant or unexpected findings in surgical pathology can significantly improve patient care. Although surgical pathology critical values have been published, no systematic assessment in pediatric surgical pathology has been published. We surveyed pediatric pathologists and pediatric subspec...

journal_title：American journal of clinical pathology

authors： Coffin CM,Spilker K,Lowichik A,Zhou H,Nielson K,Erickson L,Pysher TJ

更新日期：2007-12-01 00:00:00

abstract：:We examined benign and malignant mesothelial tissue samples for the presence of X-linked inhibitor of apoptosis protein (XIAP), a potent constituent of the inhibitor of apoptosis family of caspase inhibitors. We subjected 55 sections (31 malignant mesotheliomas, 2 well-differentiated peritoneal mesotheliomas, 13 pleur...

journal_title：American journal of clinical pathology

authors： Wu M,Sun Y,Li G,Desman G,Wang B,Gil J,Burstein DE

更新日期：2007-11-01 00:00:00

abstract：:We studied the histologic and multiparameter flow cytometry (MFC) features of 12 cases of angioimmunoblastic T-cell lymphoma (AITL), 13 of mature T-cell lymphoma, and 25 control cases of reactive lymphoid hyperplasia to evaluate the role of CD10 in the differential diagnosis of peripheral T-cell lymphomas (PTCLs). A c...

journal_title：American journal of clinical pathology

authors： Stacchini A,Demurtas A,Aliberti S,Francia di Celle P,Godio L,Palestro G,Novero D

更新日期：2007-11-01 00:00:00

abstract：:We developed anecdotal evidence that parenteral iron therapy is associated with a characteristic pattern of iron staining in bone marrow aspirate smears. In this pattern, uniform blue granules are observed within reticuloendothelial cells/stromal cells with Prussian blue staining, many times in curvilinear arrays. To ...

journal_title：American journal of clinical pathology

authors： Thomason RW,Lavelle J,Nelson D,Lin K,Uherova P

更新日期：2007-10-01 00:00:00

abstract：:With the new screening and treatment guidelines and the prospect of human papillomavirus vaccination for adolescents, the current total volume of Papanicolaou (Pap) tests will be significantly reduced. We used available data to assess the current supply and demand in the cytotechnology labor market and how an expected...

journal_title：American journal of clinical pathology

authors： Eltoum IA,Roberson J

更新日期：2007-10-01 00:00:00

abstract：:Reports of sex steroid receptor expression in chordoma suggest that these tumors may be responsive to hormone manipulation therapy. Immunohistochemical stains for estrogen receptor (ER)-alpha, ER-beta, progesterone receptor (PR), androgen receptor (AR), and cyclooxygenase 2 (COX-2), were performed on a tissue microarr...

journal_title：American journal of clinical pathology

authors： Fasig JH,Dupont WD,Olson SJ,Lafleur BJ,Cates JM

更新日期：2007-09-01 00:00:00

abstract：:The performance characteristics of the XE-2100 (Sysmex, Kobe, Japan) automated immature granulocyte (IG) count were studied. The automated IG count was compared with the manual morphology count and with a proposed reference flow cytometric count. The comparison data were analyzed by both least-squares and Passing-Babl...

journal_title：American journal of clinical pathology

authors： Fernandes B,Hamaguchi Y

更新日期：2007-09-01 00:00:00

abstract：:By studying more than 1,200 patients with cutaneous melanoma and long-term follow-up, I examined the relationship between solar elastosis and age at diagnosis of melanoma, key features of melanoma, and the outcome of overall survival in melanoma. I found that melanomas with elastosis were diagnosed significantly later...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2007-08-01 00:00:00

abstract：:The finding of monoclonal B-cell lymphocytosis (MBL) raises questions on the nature of clonal cell expansion and its risk of progression. We identified and characterized 7 cases of clinically benign clonal B-cell lymphocytosis. The clonal lymphocytes were clearly of CD5- and non-chronic lymphocytic leukemia (CLL) phen...

journal_title：American journal of clinical pathology

authors： Amato D,Oscier DG,Davis Z,Mould S,Zheng J,Kolomietz E,Wang C

更新日期：2007-08-01 00:00:00

abstract：:Pseudomonas aeruginosa is a frequent and virulent pulmonary pathogen in patients with cystic fibrosis. If colonization is not prevented, P aeruginosa becomes permanently established and nearly always mutates into a mucoid strain. The alginate-containing matrix of the mucoid strain is thought to allow the formation of ...

journal_title：American journal of clinical pathology

authors： Pritt B,O'Brien L,Winn W

更新日期：2007-07-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is the leading cause of mortality from transfusion therapy. Recipient, donor, and blood product risk factors may have important roles in the occurrence of TRALI. A case-control pilot study of 6 TRALI cases in which HLA-antibody concordance was found and 20 control subjects...

journal_title：American journal of clinical pathology

authors： Sanchez R,Bacchetti P,Toy P

更新日期：2007-07-01 00:00:00

abstract：:We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). Specimens were analyzed for claudin-1 and claudin-3 expression using immunohistochemical...

journal_title：American journal of clinical pathology

authors： Kleinberg L,Holth A,Fridman E,Schwartz I,Shih IeM,Davidson B

更新日期：2007-06-01 00:00:00

abstract：:Three brands of blood collection tubes were studied for their influence on the prothrombin time (PT) and international sensitivity index (ISI) for 5 commercial thromboplastin reagents. With all reagents, PTs were shorter in Vacutainer (Becton Dickinson Vacutainer Systems, Plymouth, England) samples than in S-Monovette...

journal_title：American journal of clinical pathology

authors： van den Besselaar AM,Hoekstra MM,Witteveen E,Didden JH,van der Meer FJ

更新日期：2007-05-01 00:00:00

abstract：:Our aim was to study the possible association between oral lichen planus and chronic hepatitis C in patients from the state of Minas Gerais, Brazil. Two groups of patients were studied: group 1, 50 patients with oral lichen planus evaluated for the presence of chronic hepatitis C; and group 2, 215 patients with chroni...

journal_title：American journal of clinical pathology

authors： de Mattos Camargo Grossmann S,de Aguiar MC,Teixeira R,do Carmo MA

更新日期：2007-05-01 00:00:00

abstract：:Human serum contains 2 isoforms of type-5 tartrate-resistant acid phosphatase (TRACP): 5a and 5b. TRACP-5b is osteoclastic. Our goal was to determine if serum TRACP-5a could originate from inflammatory macrophages (MPhi). We stained 246 paraffin-embedded tissue samples for TRACP using monoclonal antibody 9C5 (mab9C5) ...

journal_title：American journal of clinical pathology

authors： Janckila AJ,Slone SP,Lear SC,Martin A,Yam LT

更新日期：2007-04-01 00:00:00

abstract：:Bleeding problems are symptomatic of platelet delta-storage pool diseases (SPDs) such as Hermansky-Pudlak syndrome. Although at present no cure is available for delta-SPD, early diagnosis is of great importance for prophylactic and supportive treatment. This study tested the usefulness of a flow cytometric assay for p...

journal_title：American journal of clinical pathology

authors： Maurer-Spurej E,Pittendreigh C,Wu JK

更新日期：2007-04-01 00:00:00

abstract：:The p63 gene, a member of the p53 family, is an epithelial marker expressed in embryonic ectoderm, breast myoepithelium, prostate, oral epithelium, epidermis, and urothelium. The DeltaN-p63 isoforms of p63, which are believed to behave as oncogenes, are expressed in squamous cell carcinoma, basal cell carcinoma, and t...

journal_title：American journal of clinical pathology

authors： Dotto J,Pelosi G,Rosai J

更新日期：2007-03-01 00:00:00

abstract：:The aims of this study were to compare the quality of immunohistochemical assays of estrogen receptor (ER) and progesterone receptor (PR) and to compare the intermethod variability of assays from different manufacturers. immunohistochemical staining was entrusted to the following laboratories in Japan: Kyowa Medex, de...

journal_title：American journal of clinical pathology

authors： Arihiro K,Umemura S,Kurosumi M,Moriya T,Oyama T,Yamashita H,Umekita Y,Komoike Y,Shimizu C,Fukushima H,Kajiwara H,Akiyama F

更新日期：2007-03-01 00:00:00

abstract：:A proportion of patients under surveillance for recurrent bladder carcinoma with no immediate evidence of bladder tumor recurrence have positive multitarget fluorescence in situ hybridization (FISH; UroVysion, Vysis, Downers Grove, IL) results. The course of these "anticipatory positive" cases and the time to bladder ...

journal_title：American journal of clinical pathology

authors： Yoder BJ,Skacel M,Hedgepeth R,Babineau D,Ulchaker JC,Liou LS,Brainard JA,Biscotti CV,Jones JS,Tubbs RR

更新日期：2007-02-01 00:00:00

abstract：:Borrelia burgdorferi is difficult to detect in routine biopsy material from patients with skin lesions of borreliosis. In this study, a new immunohistochemical method, focus floating microscopy (FFM), was developed to detect B burgdorferi in tissue sections and was compared with polymerase chain reaction (PCR). By usi...

journal_title：American journal of clinical pathology

authors： Eisendle K,Grabner T,Zelger B

更新日期：2007-02-01 00:00:00

abstract：:This review summarizes our experience using blinded review as a method to measure quality in surgical pathology. It details the specifics about how the review is performed, the weaknesses in the method, and then summarizes our results so far. These results suggest that error rates correlate with the individual patholo...

journal_title：American journal of clinical pathology

authors： Renshaw AA,Gould EW

更新日期：2007-01-01 00:00:00

abstract：:The Digene Hybrid Capture 2 (hc2) high-risk human papillomavirus (HPV) DNA test (Digene, Gaithersburg, MD) is widely used for triage of women with atypical squamous cells of undetermined significance. Results in a "retest zone" (weakly positive tests) are repeated up to 2 times according to the Digene-recommended algo...

journal_title：American journal of clinical pathology

authors： Muldrew KL,Beqaj SH,Han J,Lum SH,Clinard V,Schultenover SJ,Tang YW

更新日期：2007-01-01 00:00:00

abstract：:Cardiac-related death has been reported following strenuous exercise, and biochemical markers predicting adverse outcomes would be useful. Despite the fact the myeloperoxidase (MPO) release may precede myocardial injury and identify at-risk patients earlier than traditional markers, information on the effects of marat...

journal_title：American journal of clinical pathology

authors： Melanson SE,Green SM,Wood MJ,Neilan TG,Lewandrowski EL

更新日期：2006-12-01 00:00:00

abstract：:We sought to determine whether a group of cases that was relatively high in disagreements and subsequent amendments could be identified and targeted for blinded review. During a 4-year period, 8,916 surgical pathology and nongynecologic cytology cases were subjected to blinded review; of these, there were 616 disagree...

journal_title：American journal of clinical pathology

authors： Renshaw AA,Gould EW

更新日期：2006-11-01 00:00:00

abstract：:Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B...

journal_title：American journal of clinical pathology

authors： Hirshberg A,Amariglio N,Akrish S,Yahalom R,Rosenbaum H,Okon E,Kaplan I

更新日期：2006-10-01 00:00:00

abstract：:The availability of automated anti-Xa heparin assays provides the opportunity to manage patient unfractionated heparin levels directly, rather than by the activated partial thromboplastin time. Because critically ill patients can acquire an antithrombin deficiency, we compared the performance of 3 anti-Xa heparin assa...

journal_title：American journal of clinical pathology

authors： Lehman CM,Rettmann JA,Wilson LW,Markewitz BA

更新日期：2006-09-01 00:00:00

abstract：:We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Pri...

journal_title：American journal of clinical pathology

authors： Ren R,Guo M,Sneige N,Moran CA,Gong Y

更新日期：2006-09-01 00:00:00

abstract：:Plasma biomarker analysis requires intact unbiased starting material. We analyzed the effects on plasma protein profiles of protease inhibitor cocktails and preprocessing storage. Plasma from 12 healthy subjects collected with and without protease inhibitors was prepared immediately and after 2 hours of room temperatu...

journal_title：American journal of clinical pathology

authors： Ayache S,Panelli M,Marincola FM,Stroncek DF

更新日期：2006-08-01 00:00:00

abstract：:Bone marrow angiogenesis in patients with idiopathic myelofibrosis (IM) was evaluated by using a quantitative morphometric analysis test system. IM specimens had a significantly higher degree of bone marrow microvessel density (MVD) compared with control specimens. The higher degree of angiogenesis was associated with...

journal_title：American journal of clinical pathology

authors： Ni H,Barosi G,Hoffman R

更新日期：2006-08-01 00:00:00

abstract：:Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2...

journal_title：American journal of clinical pathology

authors： Magro CM,Seilstad KH,Porcu P,Morrison CD

更新日期：2006-07-01 00:00:00

abstract：:Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids. The enzyme expression is minimal in adult tissues and very high in many cancers. Ulcerative colitis is a chronic inflammatory bowel disease that, when long-standing, is associated with an increased risk of colon cancer. The aim of...

journal_title：American journal of clinical pathology

authors： Consolazio A,Alò PL,Rivera M,Iacopini F,Paoluzi OA,Crispino P,Pica R,Paoluzi P

更新日期：2006-07-01 00:00:00

abstract：:To increase transplantation access, particularly in living-donor renal transplantation, efforts have been made to overcome the barrier of ABO incompatibility. In adults, the most successful cases have involved renal transplantation. Although the overall goal of reducing antibodies against donor ABO before and after tr...

journal_title：American journal of clinical pathology

authors： Warner PR,Nester TA

更新日期：2006-06-01 00:00:00

abstract：:Colorectal cancer with microsatellite instability (MSI) may occur sporadically or be inherited in cases of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. However, there is no consensus as to which patients must be tested and how to test MSI. In this study, MSI was tested by immunohistochemical analysis an...

journal_title：American journal of clinical pathology

authors： Bouzourene H,Taminelli L,Chaubert P,Monnerat C,Seelentag W,Sandmeier D,Andrejevic S,Matter M,Bosman F,Benhattar J

更新日期：2006-06-01 00:00:00

abstract：:Coronary artery disease (CAD) is the leading cause of death in the United States. Increasing evidence suggests involvement of inflammation in the atherosclerotic process. We examined cytokines and other inflammatory markers in 865 patients with chest pain in whom coronary angiography revealed no evidence of CAD or CAD...

journal_title：American journal of clinical pathology

authors： Martins TB,Anderson JL,Muhlestein JB,Horne BD,Carlquist JF,Roberts WL,Carlquist JF

更新日期：2006-06-01 00:00:00

abstract：:Fine-needle aspiration (FNA) is the standard of care for the initial workup of thyroid nodules, but there is no consensus algorithm to manage patients with benign results. We examined performance characteristics of initial and repeat satisfactory FNAs for all 402 patients who underwent thyroid surgery during a recent ...

journal_title：American journal of clinical pathology

authors： Flanagan MB,Ohori NP,Carty SE,Hunt JL

更新日期：2006-05-01 00:00:00

abstract：:We obtained data on laboratory turnaround time (TAT) and emergency department (ED) length of stay (LOS). We correlated potassium test TAT outlier percentage (TAT-OP) with ED LOS and found that for each outlier percentage (potassium result > 40 minutes), a projected impact on ED LOS was approximately 2.8 additional min...

journal_title：American journal of clinical pathology

authors： Holland LL,Smith LL,Blick KE

更新日期：2006-05-01 00:00:00

abstract：:We aimed to study the expression and localization of the molecular components of enterocyte junctions in celiac disease together with the level of tyrosine phosphorylation, a phenomenon known to affect their cellular distribution and function, and to explore the influence of proinflammatory cytokines. Duodenal biopsy ...

journal_title：American journal of clinical pathology

authors： Ciccocioppo R,Finamore A,Ara C,Di Sabatino A,Mengheri E,Corazza GR

更新日期：2006-04-01 00:00:00

abstract：:High-performance liquid chromatography (HPLC) is replacing electrophoresis for identification of hemoglobin variants. Our objective was to identify unknown tall peaks with elution times and shapes of hemoglobin Barts found on hemoglobin chromatograms that could not be confirmed by alkaline and acid gel electrophoresis...

journal_title：American journal of clinical pathology

authors： Howanitz PJ,Kozarski TB,Howanitz JH,Chauhan YS

更新日期：2006-04-01 00:00:00